The southbound Jeep Wrangler crashed off the freeway south of Pomerado Road, according to the CHP.
Investigators determined speed and alcohol were factors in the crash, authorities said.
The solo-vehicle rollover crash happened near the intersection of Pomerado and Twin Peaks roads, authorities said.
The driver who hit the two vehicles suffered a fractured pelvis and was taken to the hospital, authorities said.
A big rig struck and killed a pedestrian on an access road behind a shopping center on Poway Road, authorities said.
​ Two people and two dogs were injured and a horse was killed in a crash involving a big rig and a pickup hauling a livestock trailer.
The incident happened around 10:15 a.m. Saturday.